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Adjuvant treatment strategy after curative resection for hepatocellular carcinoma

Wei Zhang, Bixiang Zhang, Xiao-ping Chen

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 155-169 doi: 10.1007/s11684-021-0848-3

Abstract: Hepatic resection represents the first-line treatment for patients with resectable hepatocellular carcinomaIn this review, we evaluated the available evidence for the efficiency of adjuvant treatments to preventThe efficacy of molecular targeted drugs as an adjuvant therapy deserves further study.Adjuvant adoptive immunotherapy can significantly improve the clinical prognosis in the early stage.The efficiency of other adjuvant treatments needs to be further confirmed by large RCT studies.

Keywords： hepatocellular carcinoma     adjuvant treatment     hepatic resection     recurrence    

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A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy

Xiaolong Wei,Chunfa Chen,Didi Xi,Jinwen Bai,Wenhe Huang,Luoxiang Rong,Mingyao Wu,Guojun Zhang

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 112-116 doi: 10.1007/s11684-014-0345-z

Abstract: The patient showed a remarkable response to four cycles of neo-adjuvant chemotherapy (partial responseMoreover, the diagnosis and treatment of NEBC based on this case and available related literature were

Keywords： neuroendocrine carcinoma     neo-adjuvant therapy     breast    

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Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 93-104 doi: 10.1007/s11684-021-0892-z

Abstract: We conducted a prospective study to assess the non-inferiority of adjuvant chemotherapy alone versusEligible patients were randomized to receive adjuvant chemotherapy or CCRT after surgery.adjuvant CCRT group.In comparison with post-operative adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferiorAdjuvant chemotherapy alone is a favorable alternative post-operative treatment.

Keywords： chemotherapy     cervical cancer     lymph node metastasis     concurrent chemoradiotherapy     quality of life    

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Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis

Hudan Pan, Yanfang Zheng, Zhongqiu Liu, Zhongwen Yuan, Rutong Ren, Hua Zhou, Ying Xie, Liang Liu

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 564-574 doi: 10.1007/s11684-018-0676-2

Abstract: modified from “Wu Tou Decoction,” was found to significantly relieve arthritis symptoms in rats with adjuvant-inducedarthritis after 30-day treatment, especially in the 24 g/kg/day group.were assessed by micro-computed tomography, and greater bone protective effect was observed with GJK treatmentmetabolomics assay of serum was conducted; 17 metabolic biomarkers showed significant correlations with treatmentmetabolism, and glycolysis metabolism were significantly associated with the effects of GJK in arthritis treatment

Keywords： rheumatoid arthritis     traditional Chinese medicine     pharmacological mechanism     metabolism     adjuvant-induced    

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Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine adjuvant

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 6,   Pages 973-984 doi: 10.1007/s11705-021-2123-1

Abstract: To increase antibody secretion and dose sparing, squalene-in-water aluminium hydrogel (alum)-stabilised emulsions (ASEs) have been developed, which offer increased surface areas and cellular interactions for higher antigen loading and enhanced immune responses. Nevertheless, the squalene (oil) in previous attempts suffered from limited oxidation resistance, thus, safety and stability were compromised. From a clinical translational perspective, it is imperative to screen the optimal oils for enhanced emulsion adjuvants. Here, because of the varying oleic to linoleic acid ratio, soybean oil, peanut oil, and olive oil were utilised as oil phases in the preparation of aluminium hydrogel-stabilised squalene-in-water emulsions, which were then screened for their stability and immunogenicity. Additionally, the underlying mechanisms of oil phases and emulsion stability were unravelled, which showed that a higher oleic to linoleic acid ratio increased anti-oxidative capabilities but reduced the long-term storage stability owing to the relatively low zeta potential of the prepared droplets. As a result, compared with squalene-in-water ASEs, soybean-in-water ASEs exhibited comparable immune responses and enhanced stability. By optimising the oil phase of the emulsion adjuvants, this work may offer an alternative strategy for safe, stable, and effective emulsion adjuvants.

Keywords： pickering emulsion     vaccine adjuvant     alum-stabilised emulsion     oleic to linoleic acid ratio     stability    

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Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma

Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 430-435 doi: 10.1007/s11684-010-0700-7

Abstract: This study aimed to investigate the effect of adjuvant therapy on the treatment of stage II pancreaticThe MST was 399 days for those with adjuvant therapy, 210 days for those without adjuvant therapy, 390The adjuvant therapy could not prolong the survival time and decrease the liver metastasis rate of theIn the bypass operation and laparotomy group and nonsurgical group, the adjuvant therapy could improveThe proper adjuvant therapy can be suggested according to the general condition of the patients after

Keywords： pancreatic neoplasms     neoadjuvant therapy     survival    

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Occurrence and migration of microplastics and plasticizers in different wastewater and sludge treatmentunits in municipal wastewater treatment plant

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 11, doi: 10.1007/s11783-022-1577-9

Abstract:

● Reduce the quantifying MPs time by using Nile red staining.

Keywords： Microplastics     Municipal wastewater treatment plant     Phthalate esters     Thermal hydrolysis    

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Seasonal and treatment-process variations in invertebrates in drinking water treatment plants

Zhiling Wu, Xianchun Tang, Hongbin Chen

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 4, doi: 10.1007/s11783-020-1354-6

Abstract: Abstract • Seasonal and treatment-process variations in invertebrates in a DWTP were analyzed. • TheWe performed a monthly survey of invertebrate abundance and taxa in the effluent of each treatment stagein a drinking water treatment plant between May 2015 and April 2016 and analyzed seasonal and treatment-processThe dominant taxa in the effluent of each treatment stage were rotifers, nematodes, and crustaceans.The proportion of endogenous invertebrates gradually increased along the treatment process.

Keywords： Invertebrates     Drinking water     Seasonal variations     Treatment process    

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Special issue on “Membranes and Water Treatment”

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 5,   Pages 561-563 doi: 10.1007/s11705-021-2136-9

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Impacts of advanced treatment processes on elimination of antibiotic resistance genes in a municipalwastewater treatment plant

Lian Yang, Qinxue Wen, Zhiqiang Chen, Ran Duan, Pan Yang

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1116-5

Abstract:

The distributions of ARGs were monitored in a WWTP in Harbin during six months.

CASS had the best removal efficacy of ARGs compared to other processes in the WWTP.

UV disinfection could effectively control the HGT.

AGAC significantly remove ARGs and organics due to its high absorption capacity.

Combination of ozone and AGAC significantly improve removal of ARGs and organics.

Keywords： Antibiotic resistance genes (ARGs)     Wastewater treatment plant (WWTP)     Ultraviolet (UV)     Ozonation     Granular    

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Comparative genotoxicity of water processed by three drinking water treatment plants with different watertreatment procedures

Ting Zhang, Heze Liu, Yiyuan Zhang, Wenjun Sun, Xiuwei Ao

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 3, doi: 10.1007/s11783-020-1214-4

Abstract: Genotoxicity of substances is unknown in the water after treatment processes.Genotoxicity decreased by activated carbon treatment but increased by chlorination.Advanced water treatment is commonly used to remove micropollutants such as pesticides, endocrine disruptingchemicals, and disinfection byproducts in modern drinking water treatment plants.In this study, samples were collected from three drinking water treatment plants with different treatment

Keywords： Drinking water     Treatment process     Genotoxicity     Umu test     Ecological Structure-Activity Relationship    

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Microplastics in municipal wastewater treatment plants: a case study of Denizli/Turkey

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 8, doi: 10.1007/s11783-023-1699-8

Abstract:

● High amounts of microplastics are released to receiving media from WWTPs.

Keywords： Microplastics     Wastewater treatment plant     Removal efficiency     Daily discharge    

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Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China

Rui Yu,Rong Fan,Jinlin Hou

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 135-144 doi: 10.1007/s11684-014-0331-5

Abstract: Different treatment strategies have been explored to improve patient outcomes in a cost-effective mannerThe results of these studies are crucial in further improving treatment outcomes.

Keywords： chronic hepatitis B     epidemiology     prevention     treatment    

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Inactivation and risk control of pathogenic microorganisms in municipal sludge treatment: A review

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 6, doi: 10.1007/s11783-021-1504-5

Abstract:

• Diversity and detection methods of pathogenic microorganisms in sludge.

Keywords： Sludge treatment     Pathogenic microorganisms     Inactivation mechanisms     Exposure risks     Land application    

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Title Author Date Type Operation

Adjuvant treatment strategy after curative resection for hepatocellular carcinoma

Wei Zhang, Bixiang Zhang, Xiao-ping Chen

Journal Article

A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy

Xiaolong Wei,Chunfa Chen,Didi Xi,Jinwen Bai,Wenhe Huang,Luoxiang Rong,Mingyao Wu,Guojun Zhang

Journal Article

Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage

Journal Article

Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis

Hudan Pan, Yanfang Zheng, Zhongqiu Liu, Zhongwen Yuan, Rutong Ren, Hua Zhou, Ying Xie, Liang Liu

Journal Article

Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine adjuvant

Journal Article

Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma

Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,

Journal Article

Occurrence and migration of microplastics and plasticizers in different wastewater and sludge treatmentunits in municipal wastewater treatment plant

Journal Article

Luo Jun: Treatment Selection in Prostate Cancer（2019.8.16）

22 Apr 2021

Conference Videos

Seasonal and treatment-process variations in invertebrates in drinking water treatment plants

Zhiling Wu, Xianchun Tang, Hongbin Chen

Journal Article

Special issue on “Membranes and Water Treatment”

Journal Article

Impacts of advanced treatment processes on elimination of antibiotic resistance genes in a municipalwastewater treatment plant

Lian Yang, Qinxue Wen, Zhiqiang Chen, Ran Duan, Pan Yang

Journal Article

Comparative genotoxicity of water processed by three drinking water treatment plants with different watertreatment procedures

Ting Zhang, Heze Liu, Yiyuan Zhang, Wenjun Sun, Xiuwei Ao

Journal Article

Microplastics in municipal wastewater treatment plants: a case study of Denizli/Turkey

Journal Article

Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China

Rui Yu,Rong Fan,Jinlin Hou

Journal Article

Inactivation and risk control of pathogenic microorganisms in municipal sludge treatment: A review

Journal Article